MPO – Communicable Diseases Research

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patients

Research article

Published on 2022-09-012022-10-05
Journal: Blood cells, molecules & diseases
[Category] 바이오마커, 진단,

NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study

패혈성 쇼크 및 심각한 COVID-19 환자의 NETosis 및 뉴클레오솜 바이오마커: 관찰 연구

Observational Study

Published on 2022-07-272022-09-11
Journal: Biomolecules
[Category] MERS, 바이오마커, 임상,

[키워드] alternative Biomarker Biomarkers cell death conditions Control control subject COVID-19 Critical critical COVID-19 patient critical COVID-19 patients Defense discrimination disease severity evaluate extracellular trap histone ICU Infection Intact intensive care intensive care unit marker matched control mechanism microorganisms MPO myeloperoxidase NET NETosis NETs NETs’ formation neutrophil neutrophil activation neutrophil count Neutrophil elastase Neutrophil extracellular traps Neutrophils normalization Nucleosome nucleosomes P -value p -values patient cohort patients phagocytosis recruited Result SARS-CoV-2 septic Septic shock Septic shock. Significant significant differences Spread subject were measured
[DOI] 10.3390/biom12081038 PMC 바로가기 [Article Type] Observational Study

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience
[Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

A Case Report of MPO-ANCA-Associated Vasculitis Following Heterologous mRNA1273 COVID-19 Booster Vaccination

이종 mRNA1273 COVID-19 추가 백신 접종 후 MPO-ANCA 관련 혈관염 증례 보고

Case Reports

Published on 2022-07-042022-09-11
Journal: Journal of Korean medical science
[Category] MERS, 바이오마커, 진단,

[키워드] ANCA-vasculitis antibody Antineutrophil cytoplasmic antibody booster booster vaccination clinical trial constitutional symptoms coronavirus disease Coronavirus disease 2019 COVID-19 crescentic glomerulonephritis Cyclophosphamide cytoplasmic diagnosed followed by Glomerulonephritis Heterologous Increases intravenous kidney Methylprednisolone Methylprednisolone sodium succinate Moderna MPO mRNA mRNA1273 mRNA1273 COVID-19 Vaccine. past history Plasmapheresis pulse reduced regimen renal function report safety profile Side effect sodium sodium succinate steroid Symptom therapy Treatment vaccination Vaccine Vaccines Vasculitis
[DOI] 10.3346/jkms.2022.37.e204 PMC 바로가기 [Article Type] Case Reports

A diminished immune response underlies age-related SARS-CoV-2 pathologies

감소된 면역 반응은 연령 관련 SARS-CoV-2 병리의 기초가 됩니다

Article

Published on 2022-06-282022-09-12
Journal: Cell Reports
[Category] COVID19(2023년), MERS, SARS, 진단,

Late Onset of ANCA Vasculitis as a Side Effect of Levamisole Treatment in Nephrotic Syndrome

신증후군에서 Levamisole 치료의 부작용으로 ANCA 혈관염의 늦은 발병

Case Reports

Published on 2022-05-112022-09-11
Journal: Medicina
[Category] MERS, 바이오마커, 진단,

[키워드] Administered affected age alterations ANCA-vasculitis antibody Arthritis autoantibody Awareness Bilirubin Case report celiac disease children circulating clinical manifestation clinical manifestations clinician cocaine cocaine abuse COVID-19 vaccine cumulative cytopenia cytoplasmic decrease demonstrated diagnosed direct bilirubin disease dose drug reaction Effect Fever foot hand high fever induce initial injection joint lack Levamisole liver enzyme liver enzymes manifestation MPO myeloperoxidase nephrotic syndrome nephrotic syndrome. nine Onset positive raise receive reduction in reported returned second dose secondary to side Side effect Side effects steroid Symptom Symptoms syndrome the patient total and direct bilirubin treated Treatment vaccination Vasculitis was measured
[DOI] 10.3390/medicina58050650 PMC 바로가기 [Article Type] Case Reports

Imaging of innate immunity activation in vivo with a redox-tuned PET reporter

Research

Published on 2022-02-212022-10-05
Journal: Nature biotechnology
[Category] 바이오마커,

Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

중증 COVID-19 환자의 렉틴 및 대체 경로를 통한 보완 활성화

Immunology

Published on 2022-02-022022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] activate activated Activation Acute kidney injury acute respiratory syndrome addition Alternative pathway alveolar alveolar septa analyzed Autopsy both groups both lungs C1q C3c C5b-9 causes cerebral hemorrhage CFD characterized collateral tissue complement Complement activation complement deposition Control correlated correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokines Defense deposit deposition deregulated died edema Factor followed by hyaline membrane hyaline membranes Immune cell immune cells immune system immunohistochemistry in both groups indicated Inflammatory response Injury investigated involved kidney kidneys lectin lectin pathway Local lung Lung injury Lungs MASP-2 membranes Mortality MPO myeloperoxidase neutrophil Neutrophils occurred Pathogens Patient patients with COVID-19 peritubular capillaries peritubular capillary positive Prevent pro-inflammatory cytokines Pulmonary embolism respiratory SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV-2 virus particle SARS-CoV-2 virus particles semi-quantitative Severe acute respiratory syndrome severe COVID-19 SIGN significantly significantly higher significantly more Spike protein subsequent thrombi tissue damage tissue injury Treatment with COVID-19 worsening
[DOI] 10.3389/fimmu.2022.835156 PMC 바로가기 [Article Type] Immunology

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

호중구는 Covid-19 뇌졸중 환자에서 뇌 혈전의 면역 시그니처를 우세합니다.

Multicenter Study

Published on 2022-02-012022-09-10
Journal: Acta Neuropathologica Communications
[Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술,

[키워드] ACE2 expression cells Chain Reaction characterized complement complex conducted Control control patients controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients docking Endovascular treatment Evidence expressed expression level Factor Features FIBRIN immune signature increased risk infected with COVID-19 Ischemic Stroke large vessel lymphocyte macrophages molecular Monocytes monocytes/macrophage monocytes/macrophages mortality rates MPO NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils pathological analysis Patient patients Platelet Platelets polymerase chain polymerase chain reaction Ratio receptor ACE2 red blood cells retrieved ROC analysis SARS-CoV-2 SARS-CoV2 Sequencing severity stroke supplementary material the SARS-CoV-2 thrombi thrombosis thrombotic Thrombotic events Thrombus von Willebrand factor
[DOI] 10.1186/s40478-022-01313-y PMC 바로가기 [Article Type] Multicenter Study